磷酸化原癌基因c-Jun抗体简介说明书

英文名称：phospho-c-Jun (Thr91)：
中文名称：磷酸化原癌基因c-Jun抗体：：
产品类型：磷酸化抗体：
研究领域：肿瘤  细胞生物  免疫学  信号转导  转录调节因子  表观遗传学：  
抗体来源：Rabbit：
克隆类型：Polyclonal：
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,：
产品应用：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.：
分 子 量：43kDa：
细胞定位：细胞核：
性：状：Lyophilized or Liquid：
浓：度：1mg/ml：
免 疫 原：KLH conjugated Synthesised phosphopeptide derived from human c-Jun around the phosphorylation site of Thr91:TT(p-T)PT：
亚：型：IgG：
纯化方法：affinity purified by Protein A：
储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.：
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.：
PubMed：PubMed：


产品介绍：The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
   
C-jun(Oncoprotein C-jun：active protein 1)基因与鸟类肉瘤病毒17的转化基因具有同源性，是早期应答基因家族成员之一。主要用于各种恶性肿瘤的研究。 C-jun又称：应激活化蛋白激酶。