轴丝动力蛋白10抗体说明书

英文名称    DNAH10    

中文名称    轴丝动力蛋白10抗体    

别    名    axonemal; Axonemal beta dynein heavy chain 10; Ciliary dynein heavy chain 10; DNAH10; DYH10_HUMAN; Dynein heavy chain 10; KIAA2017.    

供应商    远慕生物

研究领域    神经生物学  信号转导  细胞粘附分子  细胞骨架  细胞外基质      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 轴丝动力蛋白10抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    515kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DNAH10    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

轴丝动力蛋白10抗体产品介绍    background:

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]

Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.

Subunit:
Consists of at least two heavy chains and a number of intermediate and light chains. 

Subcellular Location:
Cytoplasm. cytoskeleton. cilium axoneme.

Tissue Specificity:
Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.

Similarity:
Belongs to the dynein heavy chain family. Contains 5 TPR repeats.

Gene ID:
196385

Database links:

Entrez Gene: 196385 Human

Omim: 605884 Human

SwissProt: Q8IVF4 Human

Unigene: 622654 Human