21号染色体开放阅读框106抗体说明书

英文名称    C21orf106/DIP2A    

中文名称    21号染色体开放阅读框106抗体    

别    名    C21orf106; DIP 2A; DIP2; DIP2 disco interacting protein 2 homolog A; DIP2 homolog A; DIP2A; DIP2 like protein; Disco interacting protein 2 homolog; KIAA0184; DIP2A_HUMAN.    

供应商      远慕生物   

研究领域    细胞生物  细胞周期蛋白  转录调节因子  细胞分化  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）21号染色体开放阅读框106抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    170kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DIP2A/C21orf106    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

21号染色体开放阅读框106抗体产品介绍    background:

DIP2A, also known as DIP2, is a 1571 amino acid nuclear protein. It is one of three human homologs (DIP2A, DIP2B and DIP2C) of the Drosophila dip2 (disconnected-interacting protein 2) protein. In Drosophila, dip2 interacts with disco, a protein required for neuronal connections in the visual systems of larvae and adults. The closest vertebrate homologs to disco are the basonuclin genes. In mice, DIP2 homologs show restricted expression to the brain. This suggests that, similar to the function of Drosophila dip2, vertebrate DIP2 homologs may play a role in the development of the nervous system. Expressed ubiquitously with highest expression in the brain, DIP2A is thought to function in signaling throughout the central nervous system by providing positional clues for axon patterning and pathfinding. Four isoforms of DIP2A exist due to alternative splicing events.

Function:
May provide positional cues for axon pathfinding and patterning in the central nervous system. 

Subcellular Location:
Nuclear

Tissue Specificity:
Low expression in all tissues tested. 

Similarity:
Belongs to the DIP2 family.